The present invention provides antibodies that bind to Staphylococcus aureus Hemolysin A toxin, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Hemolysin A. The antibodies of the invention are useful for inhibiting or neutralizing Hemolysin A activity, thus providing a means of preventing or treating a Hemolysin A-related disease or disorder such as S. aureus infection. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of a S. aureus infection.本發明提供結合於金黃色葡萄球菌溶血素A毒素之抗體及使用方法。根據本發明之某些實施例,該等抗體為結合於溶血素A之完全人類抗體。本發明之抗體適用於抑制或中和溶血素A活性,因此提供預防或治療諸如金黃色葡萄球菌感染之溶血素A相關疾病或病症之手段。在一些實施例中,本發明之抗體用於治療金黃色葡萄球菌感染之至少一種症狀或併發症。