A fenestration system can be useful for draining cysts, abscesses, or other bodily cavities. A fenestration system can include: a drainage screwdriver a drainage screw removably receivable onto the drainage screwdriver and a drainage cap removably coupleable with the drainage screw when the drainage screw removed from the drainage screwdriver. The drainage screwdriver can receive the drainage screw so that the drainage screw can be screwed through tissue and/or cyst or abscess sac. The drainage screwdriver can then release the drainage screw so that it is inserted into the tissue, cyst, or abscess so as to be capable of drainage. A lumen in the drainage screw can function similarly to a drainage tube. The drainage cap can be applied to the drainage screw to close the lumen to inhibit other fluids or particles from entering into the tissue, cyst, or abscess via the lumen.
