The invention generally related to new medical uses of fungal immunomodulatory proteins. More particularly, the invention relates to using a fungal immunomodulatory protein and compositions containg a fungal immunomodulatory protein for inhibition of osteoclastogenesis, inhibition of bone resorption, and prevention and treatment of bone loss-associated diseases.本發明大致上關於真菌免疫調節蛋白的新醫藥用途。更特定地說,本發明關於運用真菌免疫調節蛋白以及含有真菌免疫調節蛋白的組成物來抑制蝕骨細胞新生作用、抑制骨質再吸收,以及預防和治療骨質流失相關性疾病。