Marco Bernardini,Francesca Borgo,Giorgio Freschi,Edoardo Russo
申请号：
US13464563
公开号：
US09764302B2
申请日:
2012.05.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A continuous process for preparing microcapsules containing water-insoluble active principles, comprising:(1) preparing, in a first reactor, an aqueous solution containing one or more surfactants,(2) preparing, in a second reactor, a solution comprising at least an active principle immiscible in an aqueous phase and a first component for preparing a polycondensation polymer for forming the microcapsule shell,simultaneously feeding to a tubular reactor of a stream of aqueous solution (1) and solution (2), the ratio of solution (2)/solution (1) being between 0.5 and 2.0,inletting a stream (3) of a second component for preparing the polycondensation polymer into the reactor, wherein stream (3) reacts with the first component,wherein the streams are under turbulent flow conditions in the tubular reactor, and are continuously fed to the tubular reactor,and wherein the ratio between the equivalents of the first component and second component are between 0.9 and 1.1.
