DERYK T. LOO,EZIO BONVINI,JUNIPER SCRIBNER,LESLIE S. JOHNSON,LING HUANG,THOMAS SON
申请号：
BR112018071105
公开号：
BR112018071105A2
申请日:
2017.04.13
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention relates to novel b7-h3 binding molecules capable of binding to human and non-human b7-h3 and, in particular, to those molecules that are cross-reactive with b7-h3 of a non-human primate ( for example, a cynomolgus monkey). The invention additionally pertains to b7-h3 binding molecules comprising light chain variable domains and / or heavy chain (vh) domains that have been humanized and / or de-immunized so as to exhibit reduced immunogenicity upon administration to recipient subjects. . The invention particularly pertains to bispecific, trypecific or multispecific b7-h3 binding molecules, including bispecific diabodies, bites, bispecific antibodies, trivalent binding molecules, etc. which comprise: (i) such b7-h3 binding variable domains and (ii) a domain capable of binding to an epitope of a molecule present on the surface of an effector cell. The invention also relates to pharmaceutical compositions containing any such b7-h3 binding molecules, and to methods involving the use of any such b7-h3 binding molecules in the treatment of cancer and other diseases and conditions. The invention also particularly pertains to a molecule comprising the human b7-h3 binding domain of a humanized anti-human b7-h3 antibody conjugated to at least one drug moiety (a b7-h3-adc). The invention is also directed to pharmaceutical compositions containing such b7-h3-adcs, and to methods involving the use of any such b7-h3-adcs in the treatment of cancer and other diseases and conditions.a presente invenção se refere a moléculas de ligação a b7-h3 inovadoras capazes de se ligarem a b7-h3 humano e não humano e, em particular, a essas moléculas que são reativas de maneira cruzada com b7-h3 de um primata não humano (por exemplo, um macaco cynomolgus). a invenção adicionalmente pertence a moléculas de ligação a b7-h3 que compreendem domínios variáveis de cadeia leve e/ou variáveis de cadeia pesada (vh) que foram humanizados e/ou desimunizados, de modo a apres
