Massachusetts Institute of Technology;The Children's Medical Center Corporation
发明人:
Suman Bose,Volkan Yesilyurt,Lisa Rae Volpatti,Robert S. Langer,Daniel G. Anderson
申请号：
US16007922
公开号：
US20180353650A1
申请日:
2018.06.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Macrodevices containing a micro-fabricated body having at least one or multiple compartments and a porous membrane, methods of making and using thereof, are described. The one or multiple compartments encapsulate one or more cells that secrete a therapeutic agent in cell-based therapy. The porous membrane provides immunoprotection the encapsulated cells. Further, the surface of the macrodevices is chemically modified using polymers and/or small molecules, reducing fibrosis of the macrodevices, thereby allowing in vivo delivery of the secreted therapeutic agents for extended periods of time.
