Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies. In some embodiments, the conjugates are used in combination with a second therapeutic agent.本發明提供包含類鐸受體促效劑之抗體結合物及該等結合物用於治療癌症之用途。在一些實施例中,該等結合物包含抗HER2抗體。在一些實施例中,該等結合物與第二治療劑組合使用。