The present invention relates to compositions and methods for improving a subject condition by epicutaneous immunobalancing. The invention shows that particular regulatory T cells can be induced and maintained in a subject by epicutaneous treatment, thereby causing a substantial improvement in a subject condition. The invention may be used in a preventive context, to improve the immunobalance of a subject and avoid the onset or development of diseases, as well as in a therapeutic context, to improve a subject recovery. The invention is particularly suitable to prevent or treat a proliferative or autoimmune disease. The invention may be used in any mammalian subject, preferably in human subjects, including children and adults.
