Francis X. McGowan;Robert Lee;Andrew Loxley;John Kheir
发明人:
John Kheir,Francis X. McGowan,Andrew Loxley,Robert Lee
申请号：
US13884658
公开号：
US20140010848A1
申请日:
2011.11.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compressible and concentrated suspensions containing gas-filled microbubbles, uses thereof for delivering gas into a subject in need thereof, and systems for delivering the compressible suspensions. The gas-filled microbubbles each comprise a gas core surrounded by a lipid membrane, which includes (a) one or more lipids, such as 1,2-disteroyl-sn-glycero-3-phosphocholine (DSPC) or dipalmitoylphosphatidylcholine (DPPC), and (b) one or more stabilizing detergents, such as poloxamer 188, Pluronic F108, Pluronic F127, polyoxyethylene (100) stearyl ether, cholesterol, gelatin, polyvinylpyrrolidone (PVP), and sodium deoxycholate (NaDoc).
