PROBLEM TO BE SOLVED: To provide a granular preparation containing three branched-chain amino acids of isoleucine, leucine, and valine, in which granules are reduced in specific volume and have a reduced uncomfortable feeling at ingestion.SOLUTION: The granules are prepared by granulating a mixture containing branched-chain amino acid particles, followed by particle size regulation for 2 minutes to 10 hours, which is longer than conventional particle size regulation period.COPYRIGHT: (C)2011,JPO&INPIT【課題】イソロイシン、ロイシンおよびバリンからなる3種の分岐鎖アミノ酸を含有する顆粒製剤を提供するにあたり、比容積が低減され、服用に際して不快感の少ない顆粒を得る。【解決手段】分岐鎖アミノ酸粒子を含有する混合物を造粒した後、2分~10時間と、通常の整粒時間に比べて長時間整粒して、顆粒とする。【選択図】なし
