IFOM Fondazione Istituto FIRC di Oncologia Molecolare
发明人:
Sidenius, Nicolai,Gandhi, Sonu
申请号：
AU2012293720
公开号：
AU2012293720A1
申请日:
2012.08.02
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The invention relates to variants of the urokinase plasminogen activator receptor (uPAR) that display remarkably increased vitronectin (VN) binding activity, possibly caused by a more efficient exposure of the VN binding site. The present invention also refers to antibodies raised against said uPAR variants, able to bind to the VN binding site of uPAR and then acting as inhibitors of uPAR functions, acting as functional antagonists of VN activated-uPAR functions. In the present invention such antibodies are monoclonal, polyclonal, synthetic or recombinant derivatives thereof, as synthetic antibodies (scFv) from phage-display libraries. Antibodies of the invention act as competitive antagonists.
