Research Triangle Institute;Dignity Health;Virginia Commonwealth University
发明人:
Frank Ivy Carroll,Bruce E. Blough,Hernan A. Navarro,S. Wayne Mascarella,Ana Zamfira Muresan,M. Imad Damaj,Ronald J. Lukas
申请号：
US14537124
公开号：
US09527823B2
申请日:
2014.11.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
