ALBERT S. REN,GRAEME SEMPLE,MICHELLE KASEM,THOMAS O. SCHRADER,XIUWEN ZHU
申请号：
BR112019003142
公开号：
BR112019003142A2
申请日:
2017.08.18
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention relates to compounds of formula A and pharmaceutical compositions thereof that modulate 5-ht2c receptor activity. the compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in treating a 5-ht2c receptor mediated disorder, such as, weight control, satiety induction and decreased food intake, and for obesity prevention and treatment, antipsychotic-induced weight gain, type 2 diabetes, prader-willi syndrome, tobacco / nicotine addiction, drug withdrawal, abstinence from alcoholism and the like, obsessive-compulsive spectrum disorders and impulse control disorders (including nail biting and onychophagia), sleep disorders, urinary incontinence, psychiatric disorders (including schizophrenia, anorexia nervosa and bulimia nervosa), Alzheimer's disease, sexual dysfunction, erectile dysfunction, epilepsy, movement disorders (including parkinsonism and antipsychotic-induced movement disorder), hypertension, dyslipidemia, nonalcoholic fatty liver disease, obesity-related kidney disease and sleep apnea. In addition, compositions are provided comprising a compound herein, optionally in combination with a supplemental agent.a presente invenção se refere a compostos da fórmula a e composições farmacêuticas dos mesmos que modulam a atividade do receptor 5-ht2c. os compostos da presente invenção e as composições farmacêuticas dos mesmos são dirigidos a métodos úteis no tratamento de um distúrbio mediado pelo receptor 5-ht2c, tal como, controle do peso, indução da saciedade e diminuição da ingestão de alimentos, e para prevenção e tratamento da obesidade, ganho de peso induzido por antipsicóticos-, diabetes tipo 2, síndrome de prader-willi, dependência de tabaco/nicotina, abstinência de drogas, abstinência de alcoolismo e semelhantes, transtornos do espectro obsessivo-compulsivo e transtornos do controle dos impulsos (incluindo roer unha e onicofagia), distúrbi
