PROBLEM TO BE SOLVED: To provide an anti-aging agent having a more powerful sirtuin activation effect than that of resveratrol and inhibiting the aging, and a pharmaceutical composition and foodstuff containing the anti-aging agent.SOLUTION: An activating agent, pharmaceutical composition and foodstuff are provided by containing an extract of the fruit or seed of melinjo which is a plant of Gnetaceae, or gnetin C, as an active ingredient, having the activation effect of the sirtuin having an NAD-dependent deacetylation enzyme activity associated with the realization of the prolongation of life, since calorie restriction is an effective treatment for realizing the prolongation of the life and anti-aging.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】レスベラトロールより強力なサーチュイン活性化作用を持ち、老化を抑制する抗老化剤、並びに抗老化剤を含む医薬組成物、食品を提供。【解決手段】カロリー制限が延命・抗老化を実現するための有効な処理で、その延命の実現に関与するNAD依存性脱アセチル化酵素活性を有するサーチュインの活性化作用を有する、グネツム科植物であるメリンジョの実または種子の抽出物またはグネチンCを有効成分とする活性化剤、医薬組成物及び食品。【選択図】図1
