Lynnie TRZOSS,Juan Manuel BETANCORT,Toufike KANOUNI,Michael Brennan WALLACE,Amogh BOLOOR
申请号：
US15956434
公开号：
US20180296543A1
申请日:
2018.04.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.
