#$%^&*AU2015210336A120150827.pdf#####RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) Abstract -y-[ER(P-- laserk,-2-- 2.---n--, Eiiniii d e eaivii dg of Tr g amisikM du~Mx the modulaion of HB genepexprso and/or acetivtadoMouaeaHVgn / NP NTort RISCl~o expressI pathway.--------- Specifically,-- theC inenin laes odul-trne uli IN*A nPhaW .~u K 4by RdRR F \ia- I2H-H1 7571 Httfl jjjli Ij OM "II HI by DUM (Fbszct 20N, Sx,-im ENonudse CL7mwge of Thrget FIG.1 M$, 1i6,11-265) The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of HBV gene expression and/or activity, and/or modulate a HBV gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against HBV gene expression.
