Bayle, Joseph Henri,Duong, MyLinh Thi,Collinson-Paulz, Matthew Robert,Foster, Aaron Edward,Spencer, David Michael
申请号:
AU2016370470
公开号:
AU2016370470A1
申请日:
2016.12.13
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The technology relates in part to methods for controlling the activity or elimination of therapeutic cells using molecular switches that employ distinct heterodimerizer ligands, in conjunction with other multimeric ligands. The technology may be used, for example to activate or eliminate cells used to promote engraftment, to treat diseases or condition, or to control or modulate the activity of therapeutic cells that express chimeric antigen receptors or recombinant T cell receptors.