PURPOSE: A pharmaceutical composition containing telmisartan as an active ingredient with enhanced stability is provided to save time and costs by a simple manufacturing process and to improve drug compliance by minimizing formulation volume. CONSTITUTION: A pharmaceutical composition contains telmisartan or a pharmaceutically acceptable salt thereof as an active ingredient and also contains an alkali metal phosphate compound as a solubilizing agent. The composition additionally contains a soluble diluent. The alkali metal phosphate compound is Na_3PO_4 or K_3PO_4. A method for manufacturing the pharmaceutical composition comprises the steps of: dissolving a first pharmaceutical ingredient and a phosphate compound in a solvent to prepare a first liquid； dispersing a second pharmaceutical ingredient and a surfactant in a solvent to prepare a second liquid； spraying the first liquid to a pharmaceutically acceptable excipient and preparing granules； spraying the second liquid to the granules and preparing double-coated granules； and filling or tableting the double-coated granules. [Reference numerals] (AA) Elution rate (%)； (BB) Example 2； (C1) Comparative example 1； (C2) Comparative example 2； (C3) Comparative example 3； (DD) Time (min)본 발명은 텔미사르탄을 유효성분으로 포함하는 약제학적 조성물로서, 알칼리 금속 인산염을 포함하는 것을 약제학적 조성물이다. 본 발명은 제조공정을 간단하게 하여 시간적 및 비용적 측면에서 크게 개선되었을 뿐만 아니라 제제 총 용량이 최소화되어 환자의 복약 순응도를 향상시킬 수 있으면서 동시에, 흡습성을 개선하여 보다 안정한 복합제를 제공한다.
