WUHAN INSTITUTE OF PHYSICS AND MATHEMATICS; CHINESE ACADEMY OF SCIENCES
发明人:
Yang Wu,Fuqiang Xu,Xiaobin He
申请号：
US15884470
公开号：
US10501758B2
申请日:
2018.01.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A recombinant baculovirus, including: an adeno-associated virus Rep gene, an adeno-associated virus Cap gene, and an recombinant adeno-associated virus genome ITR-GOI (gene of interest) flanked by rAAV inverted terminal repeats (ITR). The ITR-GOI includes a 5′； terminal nucleic acid fragment and a 3′； terminal nucleic acid fragment. The ITR-GOI is linked to an expression cassette of the Cap gene and an expression cassette of the Rep gene through the 5′； terminal nucleic acid fragment and the 3′； terminal nucleic acid fragment, respectively.
