He LI,Tina ALBERTSON,Mark D. HEIPEL,Claire L. SUTHERLAND
申请号：
US16465141
公开号：
US20200078400A1
申请日:
2017.12.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are methods of determining dosing of cells engineered with a recombinant receptor, such as a T cell receptor (TCR) or chimeric antigen receptor (CAR). In some embodiments, the methods include determining a therapeutic range for dosing by the estimated probabilities of risk of developing a toxicity and estimated probabilities of response to the engineered cells when administered.
