KIM, MIN SANG,김민상,KIM, HYUN RYOUNG,김현령,PARK, JAE CHAN,박재찬,CHAE, SU YOUNG,채수영,PARK, SUN MIN,박선민
申请号：
KR1020110107055
公开号：
KR1020130042905A
申请日:
2011.10.19
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A liposome containing an elastine-like polypeptide(ELP) and a use thereof are provided to reduce the amount of drug release, and to maintain stable state. CONSTITUTION: A liposome contains: a lipid bilayer； an elastine-like polypeptide(ELP) in which hydrophobic group-containing moiety is conjugated； and a lipid bilayer stabilizing agent. The moiety is filled in the lipid bilayer. The lipid bilayer stabilizing agent is steroid which is incorporated in the lipid bilayer. The lipid bilayer stabilizing agent is selected from the group consisting of sterol or a derivative thereof, spingolipid or a derivative thereof, and a combination thereof. The lipid bilayer stabilizing agent is selected from the group consisting of cholesterol, beta-cholesterol, sistosterol, ergosterol, stigmasterol, 4,22 stigmastadiene-3-one, stigmasterol acetate, lanosterol, and a combination thereof. [Reference numerals] (AA) Calcein release(%)； (BB) Cholesterol molar ratio: 25.8； (CC) Cholesterol molar ratio: 41； (DD) Temperature(°；C)；엘라스틴 유사 폴리펩티드를 포함하는 리포좀, 그를 포함하는 약학적 조성물, 및 그를 이용하여 활성성분을 표적부위에 전달하는 방법이 제공된다.
