In certain embodiments, the present invention provides a solid controlled release dosage form comprising a core comprising a core portion of an opioid antagonist, and a shell enclosing the core and comprising a shell portion of the opioid antagonist. Wherein the release characteristics of the core portion of the opioid antagonist are different from the release characteristics of the shell portion of the opioid antagonist, and are directed to the solid controlled release dosage form.ある特定の実施形態では、本発明は、オピオイド拮抗薬のコア部分を含むコアと、前記コアを包み込み、かつ、前記オピオイド拮抗薬のシェル部分を含むシェルと、を含む固体の放出制御型剤形であって、前記オピオイド拮抗薬のコア部分の放出特性が、前記オピオイド拮抗薬のシェル部分の放出特性と異なる、前記固体の放出制御型剤形を対象とする。
