Disclosed are a pharmaceutical composition including a polymeric drug carrier having enhanced stability in an aqueous solution and a method for stabilizing same. More particularly, a pharmaceutical composition in the form of an aqueous solution and a method for stabilizing same are disclosed, wherein the pharmaceutical composition maintains preservation stability for at least six months, and preferably at least 12 months in the case of refrigeration, and includes a polymeric drug carrier containing an amphiphilic block copolymer, which is composed of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative of which a bivalent or trivalent metal ion binds to a carboxyl group at a terminal thereof.L'invention concerne une composition pharmaceutique comprenant un support de médicament polymère ayant une stabilité accrue dans une solution aqueuse et un procédé de stabilisation de cette composition. Plus particulièrement, l'invention concerne une composition pharmaceutique sous la forme d'une solution aqueuse et un procédé de stabilisation de celle-ci, la composition pharmaceutique maintenant une stabilité de conservation pendant au moins six mois, et de préférence ,au moins 12 mois en cas de réfrigération, et comprenant un support de médicament polymère contenant un copolymère à blocs amphiphile, qui est composé d'un bloc hydrophile et d'un bloc hydrophobe, et un dérivé d'acide polylactique dont un ion de métal bivalent ou trivalent se lie à un groupe carboxyle à une extrémité terminale de celui-ci.수용액 상태에서 안정성이 향상된 고분자 약물 담체 함유 약학적 조성물 및 이의 안정화 방법이 개시된다. 더욱 구체적으로, 친수성 블록과 소수성 블록으로 구성된 양친성 블록 공중합체 및 말단 카르복시기에 2가 또는 3가 금속이온이 고정된 폴리락트산 유도체를 포함하는 고분자 약물 담체를 함유하며 냉장보관 시 6개월 이상, 바람직하게는 12개월 이상 보존 안정성이 유지되는 약학적 수용액 조성물 및 이의 안정화 방법이 개시된다.
