A method (200) and system (100) for determining a navigation pathway for an invasive medical instrument in a blood vessel is provided. In one aspect of the invention, the method (200) includes receiving a first medical image. The method (200) further includes determining one or more parameters associated with the first medical image. Additionally, the method (200) includes identifying a second medical image in a computer memory, based on the determined one or more parameters. Furthermore, the method (200) includes modifying the second medical image based on the first medical image. The method (200) also includes determining from the modified second medical image the navigation pathway for the invasive medical instrument.
