A method of manufacturing root of megawatt wind-turbine blade includes the following steps: (1) manufacturing an independent female mould, and arranging a positioning stop-ring on the female mould; (2) clinging on one side of the positioning stop-ring, a plurality of glass fabrics and macroporous glass fabrics are laid on the curved surface of the female mould; (3) after laying the glass fabrics, sealing the female mould using a vacuum bag, and vacuumizing the female mould after a curved supporting board is arranged on the vacuum bag; (4) after laying a plurality of glass fabrics in the blade mould, slinging the prefabricated part and the curved supporting board to arrange them in the blade mould; (5) sealing the blade mould using another vacuum bag, vacuumizing the blade mould, thereafter infusing resin into the blade mould, after curing the root of the blade is finally formed. The method of manufacturing root of megawatt wind-turbine blade increases the production efficiency and production quality of the blade root, and prolongs the operation life of the blade root.