SHANDLER, SCOTT,GELLMAN, SAMUEL H.,GLEDHILL, JOHN M.
申请号：
EP14765521
公开号：
EP2968469A4
申请日:
2014.03.17
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.
