Ho Young Song,Yun Hee Park,Sung Min Kim,Hyoung Rae Kim,Ji Hye Oh,Hyun Min Ryu,Jeiwook Chae,Yeong Soo Oh,Yong Zu Kim,Maureen Deehan,Nicolas Fischer
申请号：
US16408002
公开号：
US20200095317A1
申请日:
2019.05.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.
