In accordance with various embodiments, an intraocular manipulator is disclosed which uses negative pressure to grasp and/or manipulate an intraocular object, for example, an IOL, a crystalline lens, or an intraocular foreign body. The device comprises a tip, a stem, and a suction source. The device may be a handheld device with the negative pressure controlled by a foot pedal. Similarly, the device may be used in conjunction with other intraocular devices.