Peter Bruenker,Tanja Fauti,Christiane Jaeger,Christian Klein,Pablo Umana
申请号：
US13591024
公开号：
US20130058936A1
申请日:
2012.08.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged and wherein the bispecific antibody does not comprise a Fc domain methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
