HO, WEN-BIN,WRIGHT, LEE R,TURTLE, ERIC D,MOSSMAN, CRAIG,FLIPPIN, LEE A
申请号：
NZ59274109
公开号：
NZ592741A
申请日:
2009.11.11
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
592741 Disclosed is a compound of formula I which inhibits hypoxia inducible factor (HIF) hydroxylase enzyme activity, wherein the substituents are as described within the specification. An example of a compound of formula I is [(4-hydroxy-7-methoxy-2-oxo-2H-thiochromene-3-carbonyl)-amino]-acetic acid. Further disclosed is a pharmaceutical composition comprising a compound of formula I and the use of a compound of formula I in the manufacture of a medicament for treating a condition mediated by HIF or erythropoietin, such as myocardial infarction, congestive heart failure, or anaemia. Also disclosed is a method of inhibiting the activity of HIF hydroxylase which is not present in the human body.
