The present disclosure provides a method for treating lung cancer in a subject in need of such treatment includes administering to the subject a pharmaceutical composition. The pharmaceutical composition includes an effective amount of a betanodavirus B2 protein or a fragment thereof, or a nucleic acid molecule encoding the betanodavirus B2 protein or the fragment thereof, and optionally a pharmaceutically acceptable carrier or excipient.本發明提供一種於一需治療個體中治療肺癌的方法,包含將一醫藥組合物投予該個體。該醫藥組合物包含有效量之β野田病毒B2蛋白(betanodavirus B2 protein)或其片段,或編碼該β野田病毒B2蛋白或其片段之核酸分子,及任選的醫藥可接受之載劑或賦形劑。