combination, pharmaceutical composition, and methods of antagonizing biological activity, treating disease-related angiogenesis in a mammal, and treating cancer in a mammal
DAVID CHARLES BLAKEY,JEFFREY LESTER BROWN,STEPHEN CHARLES EMERY
申请号：
BRPI0619853
公开号：
BRPI0619853A2
申请日:
2006.12.12
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.
