< Topic >This invention, from new manufacturing method of the stomach containment die oral solid formulation, and viewpoint of control delivery of the medicine, offers the medicine solid formulation containment in the stomach or upper alimentary canal.SolutionsAforementioned production manner, it passes process and this powder blend which prepare the powder blend which includes the hydrophobic powder with the corning solution and passes the corning paste and it includes the process which corning is done and the process which makes the said paste to the solid dry. In addition. As for the aforementioned formulation, it is the formulation which can by aforementioned production manner. With aforementioned process, the starting powder process (i) and/or the corning solution process (ii), it is possible to add the active ingredient, to the starting powder process (i) desirably and, and/or it is possible to apply to the solid which is obtained with process (iii).< Choice figure >It is not【課題】本発明は、胃保持型経口固形製剤の新規製造法、および薬剤の制御送達の観点から、胃または上部消化管に保持される医薬固形製剤を提供する。【解決手段】前記製造方法は、疎水性粉末を含む粉末混合物を準備する工程、この粉末混合物を造粒溶液で過造粒ペーストに過造粒する工程、該ペーストを固形物へと乾燥させる工程を含んでいる。また。前記製剤は、前記製造方法によって得られる製剤である。前記工程では、有効成分を、工程(i)の出発粉末および/または工程(ii)の造粒溶液、好ましくは工程(i)の出発粉末に添加してもよいし、および/または工程(iii)で得た固形物に塗布してもよい。【選択図】なし
