Concentrated aqueous azalide formulation

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专利权人:

サン ファーマ グローバル エフゼットイー

发明人:

バウマン、ライル、エム．,ホウ、スイ、ユェン エディー,グエン、タン

申请号：

JP2016500903

公开号：

JP6589099B2

申请日:

2014.03.07

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

Provided is concentrated aqueous azithromycin formulation from about from about 2%-20%, and a method of making a concentrated aqueous azithromycin formulation which includes preparing and sterilizing a first solution comprising a strong base to form a sterilized solution, dissolving the azithromycin in an aqueous solution comprising an acid consisting essentially of a strong acid, and adding the aqueous solution comprising the strong acid to the sterilized solution comprising the strong base. The strong acid has a pKa less than about &minus；1.74 and the method is carried out without addition or use of a weak acid.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/