#$%^&*AU2012211353A120120823.pdf#####ABSTRACT OF THE DISCLOSURE Agonists and antagonists which modulate the activity of TWEAK and TWEAK receptor are provided. The methods, compositions and kits of the 5 invention may be employed in the treatment of disorders such as cancer and immune-related diseases. LO 3572788_1 (GHMatters) P72608.AU.1 3-Aug-12