Provided is a novel bleomycin hydrolase production promotor. Provided is a bleomycin hydrolase production promotor, natural moisturizing factor production promotor, and dry skin remedy, comprising as an active ingredient thereof one or a plurality of ingredients selected from the group consisting of chestnut rose extract, angelica root extract, cork tree bark extract, lamium album extract, rosemary extract, benzenesulfonyl GABA and erythritol.本發明提供一種新穎之博來黴素水解酵素產生促進劑。本發明提供一種含有選自由刺梨萃取物、當歸萃取物、黃柏萃取物、野芝麻萃取物、迷迭香萃取物、苯磺醯基GABA及赤藻糖醇所組成之群中之1種或複數種作為活性成分之博來黴素水解酵素產生促進劑、天然保濕因子產生促進劑、乾燥肌膚改善劑。