Charles W Rowe;Wendy E. Pryce Lewis;Michael J Cima;Peter A. Materna
发明人:
Wendy E. Pryce Lewis,Michael J Cima,Charles W Rowe,Peter A. Materna
申请号：
US12979484
公开号：
US08758658B2
申请日:
2010.12.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.
