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MANAGED ACTIVATION OF REUTERIN PRODUCTION SYSTEM
专利权人:
БИОГАЙА АБ (SE)
发明人:
РООС Стефан (SE)
申请号:
RU2010153999/15
公开号:
RU2010153999A
申请日:
2009.06.10
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. The method of controlled activation of the system of production of reuterin cell cultures of Lactobacillus reuteri, including: obtaining cell cultures of Lactobacillus reuteri, where the receipt includes the fermentation of these cell cultures; ! adding glycerol to Lactobacillus reuteri cell cultures during production, thereby causing the production of reuterin; and! preservation of the obtained reuterin in cell cultures of Lactobacillus reuteri during lyophilization and storage of Lactobacillus reuteri. ! 2. The method according to claim 1, where the fermentation comprises adding glycerol at the end of the fermentation process. ! 3. The method according to claim 1 or 2, further comprising adding at least one cryoprotectant together with glycerin to cell cultures before lyophilization. ! 4. The method according to claim 1 or 2, where from about 1 to about 500 mm glycerol is added after the fermentation step but before lyophilization in the manufacturing process. !5. A method of fermenting cell cultures of Lactobacillus reuteri, comprising filling the cell cultures with at least one of the following: 1,2-propanediol, cobalt, vitamin B12, vitamin C, glycerin, or combinations thereof, at the beginning of the fermentation step. ! 6. The product obtained by the method according to claim 1. ! 7. The product obtained by the method according to claim 2. ! 8. The product obtained by the method according to claim 3. ! 9. The product obtained by the method according to claim 4. ! 10. The product obtained by the method according to claim 5. ! 11. The product according to any one of paragraphs.6-10 for use in the treatment of disorders caused by pathogens. ! 12. The product according to any one of paragraphs.6-10 for use in the treatment of disorders caused by pathogens of the skin system. ! 13. A pharmaceutical composition comprising a product according to any one of claims 6 to 10.1. Способ контролируемой активации системы продуцирования реутерина клеточных культур Lactobac
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