MCBRIDE WILLIAM J,D SOUZA CHRISTOPHER A,GOLDENBERG DAVID M
申请号：
IN2736/DELNP/2013
公开号：
IN2013DN02736A
申请日:
2013.03.26
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes. Preferably, the diagnostic complex is of use for 18F imaging, while the therapeutic complex is of use for targeted delivery of chemotherapeutic drugs or toxins. More preferably, a chelating moiety or targetable construct may be conjugated to a targeting molecule, such as an antibody or antibody fragment, using a click chemistry reaction involving cyclooctyne, nitrone or azide reactive moieties. In most preferred embodiments, the click chemistry reaction occurs in vivo. In vivo click chemistry is not limited to 1 F labeling but can be used for delivering a variety of therapeutic and/or diagnostic agents.
