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ALGINATE OLIGOMERS FOR APPLICATION IN OVERCOMING MULTIPLE DRUG STABILITY IN BACTERIA
专利权人:
АльгиФарма АС (NO)
发明人:
ОНСОЙЕН Эдвар (NO),МИРВОЛЬД Рольф (NO),ДЕССЕН Арне (NO),ТОМАС Дэвид (GB),УОЛШ Тимоти (GB)
申请号:
RU2011148757/15
公开号:
RU2011148757A
申请日:
2010.06.03
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of overcoming resistance to at least one antibiotic in an MDR bacterium (a bacterium having multidrug resistance), comprising bringing said bacterium into contact with an alginate oligomer together with an antibiotic. The use of an alginate oligomer for the manufacture of a medicament for use with at least one antibiotic in the treatment of a subject infected, presumably infected, or at risk of infection with an MDR bacterium, to overcome antibiotic resistance in said bacterium. 3. A product containing an alginate oligomer and an antibiotic in the form of a combined preparation for the separate, simultaneous or sequential use in the treatment of a subject infected, presumably infected or at risk of infection with an MDR bacterium, to overcome antibiotic resistance in said bacterium. 4. An in vitro method of controlling the contamination of an area with an MDR bacterium, comprising contacting said area and / or said bacterium with an alginate oligomer together with an antibiotic to which said bacteria are resistant. The method of claim 1, wherein the bacterium is resistant to three or more classes of antibiotics selected from macrolides, β-lactams, tetracyclines, polypeptide antibiotics and quinolones. The method of claim 5, wherein the bacterium is resistant to three or more antibiotics selected from azithromycin, clarithromycin, dirithromycin, erythromycin, troleandomycin, roxithromycin, spiramycin, aztreonam, imipenem, meropenem, erytapenem, dorupenem, bipenem, bipenem, bipenem , cefixime, cefdinir, cefditorin�1. Способ преодоления устойчивости к по меньшей мере одному антибиотику у MDR-бактерии (бактерия, обладающая множественной лекарственной устойчивостью), включающий приведение указанной бактерии в контакт с альгинатным олигомером вместе с антибиотиком.2. Применение альгинатного олигомера для изготовления лекарственного средства для применения вместе с по меньшей мере одним антибиотиком в лечении субъекта, инфицированного, предположительно инфициро
来源网站:
中国工程科技知识中心
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