PREPARATION D'UN ANTICORPS OU D'UN IMMUNOLIPOSOME CIBLE PAR UN FRAGMENT D'ANTICORPS POUR L'ADMINISTRATION SYSTEMIQUE D'AGENTS THERAPEUTIQUES OU DIAGNOSTIQUES ET LEURS UTILISATIONS

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专利权人:

GEORGETOWN UNIVERSITY

发明人:

CHANG, ESTHER H.,PIROLLO, KATHLEEN F.

申请号：

CA2568354

公开号：

CA2568354C

申请日:

2006.12.04

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment； (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex； and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. The present invention also provides cationic immunoliposome or polymer complexes produced by such methods and compositions comprising such complexes. The present invention also provides methods for treating various diseases and disorders, including cancers, by administering the complexes and compositions of the invention to a patient.

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