Laboratorios del Dr. Esteve, S.A.;Ruprecht-Karls-Universitaet Heidelberg;Institucio Catalana de Recerca i Estudis Avancats;Fundacio Privada Institut de Recerca de la Sida - Caixa
发明人:
Izquierdo Useros, Nuria,Krausslich, Hans-Georg,Lorizate, Maier,Martínez Picado, Javier
申请号：
AU2012357968
公开号：
AU2012357968A1
申请日:
2012.12.17
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention refers to methods and compositions to prevent viral entry into cells expressing the CD169/sialoadhesin surface receptor by inhibiting the coupling of the sialyllactose molecule contained in the viral membrane gangliosides to the CD 169/ sialoadhesin receptor. The invention also pertains to vaccine compositions based on dendritic cells loaded with an antigen of interest whereby the vaccine is provided together with a composition capable of preventing viral entry into cells expressing the CD169/sialoadhesin. Moreover, the invention relates to diagnostic and therapeutic compositions that can be specifically delivered to enveloped virions wherein the diagnostic/therapeutic agent is coupled to CD169/sialoadhesin.
