ACTIVATION OF THE ENDOGENOUS ILEAL BRAKE HORMONE PATHWAY FOR ORGAN REGENERATION AND RELATED COMPOSITIONS, METHODS OF TREATMENT, DIAGNOSTICS, AND REGULATORY SYSTEMS
In one embodiment, the invention provides a method of regenerating organs and tissues in a subject suffering from one or more organ or tissue manifestations of glucose supply side associated metabolic syndrome, the method comprising: (a) confirming that the subject suffers from or is at risk for suffering from organ and/or tissue damage associated with a glucose supply side associated metabolic syndrome and (b) co-administering to the subject an effective amount of a pharmaceutical composition comprising a first and optionally a second active composition, said first active composition comprising an ileal brake hormone releasing substance encapsulated within an enteric coating which releases said substance within said subjects ileum and ascending colon causing release of at least one ileal brake hormone from L-cells of said subject, said optional second active composition being formulated in immediate and/or early release form in an over coating onto said enteric coating, wherein said second composition is beneficial to at least one aspect of said subjects metabolic syndrome manifestations. Coadministration methods with a second pharmaceutical composition are also disclosed.Dans un mode de réalisation, linvention concerne une méthode de régénération dorganes et de tissus chez un patient souffrant de manifestations, au niveau dun ou plusieurs organes ou tissus, dun syndrome métabolique associé aux apports en glucose, la méthode consistant en : (a) confirmer que le sujet souffre, ou est à risque de souffrir, de lésions dorganes et/ou de tissus en relation avec un syndrome métabolique associé aux apports en glucose et (b) co-administrer au patient une quantité efficace dune composition pharmaceutique comprenant une première et éventuellement une seconde composition active, ladite première composition active comprenant une substance stimulant la libération dhormones impliquées dans le frein iléal, encapsulée dans un enrobage entérique qui permettant la libération de lad
