The present disclosure provides Ligand-Drug Conjugates, Drug-Linkers, Linkers, and Ligand-Linker Conjugates comprising a self-stabilizing linker assembly comprising a succinimide ring or a hydrolyzed succinimide or a dilactam directly conjugated to the Ligand unit via a thioether linkage, and a base and an electron withdrawing group operably linked to stabilize the conjugate in plasma relative to a Ligand-Functional Agent Conjugate lacking the self-stabilizing linker assembly.
