Therapies effective for the treatment and prevention of cancer and other diseases are disclosed herein. These methods include the administration of therapeutically effective amounts of agents that increase the local production of effector cell-attracting chemokines within tumor lesions, with concommittant suppression of local production of undesirable chemokines that attract regulatory T(reg) cells. These methods include administering to the subject therapeutically effective amounts of a Toll-like receptor (TLR) agonist or other activator of NF-κB pathway in combination with a blocker of prostaglandin synthesis or a blocker of prostaglandin signaling, in combination with a type-1 interferon, or in combination with both a blocker of prostaglandin synthesis or signaling and with a type-1 interferon, thereby treating or preventing cancer or an infectious disease, or preventing their recurrence in the subject. Alternatively, the methods derived from the same paradigms, but aimed to treat or prevent autoimmune disease, chronic inflammatory disease, transplant rejection or GvH, include the combination of a Toll-like receptor (TLR) agonist in combination with a prostaglandin or other cAMP-activator.Linvention concerne des thérapies efficaces pour le traitement et la prévention du cancer et dautres maladies. Les méthodes selon linvention consistent à administrer des quantités thérapeutiquement efficaces dagents qui augmentent la production locale de chimiokines attirant les cellules effectrices à lintérieur de lésions tumorales, tout en supprimant la production locale de chimiokines indésirables qui attirent les lymphocytes T régulateurs. Ces méthodes consistent à administrer à un sujet des quantités thérapeutiquement efficaces dun agoniste des récepteurs de type Toll (TLR) ou dun autre activateur de la voie NF-κB en association avec un bloqueur de la synthèse des prostaglandines ou un bloqueur de la signalisation des prostaglandines, en association avec un interféron de ty
