The present invention describes pharmaceutical compositions of nasal spray/drops for systemic delivery of drugs. The pharmaceutical nasal spray/drops composition which comprises nanosuspension phase which contains drug in form of nanosuspension which is stabilized either by surfactants or polymers or their combination and in-situ gelling phase which contains in-situ gelling polymer with other ingredients pH modifier, preservative etc. These two phases are mixed to form uniform dispersion of nanosuspension in in- situ gelling phase.
