PROBLEM TO BE SOLVED: To create such a gene expressing a complement control factor that transplanted cells, transplanted tissue or transplanted organ is resistant to human serum by expressing the complement control factor, but PERV(swine endogenous retrovirus) produced by the transplanted cells, transplanted tissue or transplanted organ is not resistant to human serum.SOLUTION: The gene is such as to encode a fused protein of a fatty acid raft existing on animal cell membrane, a transmembrane domain protein having no affinity or suppressed in affinity for the fatty acid raft and the complement control factor or its partial protein.COPYRIGHT: (C)2008,JPO&INPIT【課 題】本発明は、移植細胞、移植組織または移植臓器は補体制御因子を発現してヒト血清に対し抵抗性を有するが、該移植細胞、移植組織または移植臓器が産生するPERVはヒト血清に対し抵抗性を有さない補体制御因子の発現遺伝子を創製すること。【解決手段】動物細胞膜上に存在する脂肪酸ラフトと親和性を有さないか脂肪酸ラフトとの親和性が抑制された膜貫通ドメイン蛋白質と補体制御因子またはその部分蛋白質との融合蛋白質をコードする遺伝子。【選択図】なし
