A grid calibration system employing interventional equipment including one or more interventional tools (23), a grid (22) having a hole matrix for supporting and guiding the interventional tool(s) (23) within a calibration area, and an imaging device (24) positioned relative to the grid (22) for generating a tool image illustrative of the interventional tool(s) (23) within the calibration area. The grid calibration system further employs a grid calibration workstation (40) for displaying any alignment adjustments to the relative positioning of the grid (22) and the imaging device (24) as derived from an image registration of the tool image and a virtual grid having a point matrix representative of the hole matrix of the grid.
