A biopsy device (100), comprising: a cannula (102) comprising an elongate cannula body (106) extending between a cannula distal end (108) and a cannula proximal end (110) to define a lumen (112), wherein the cannula comprises a cutting portion at the cannula distal end (108)； a stylet (104) comprising an elongate body (116) having a stylet distal end (118) and a stylet proximal end (120), the stylet (104) being slidably disposed within the lumen (112), wherein the stylet (104) comprises a tissue sampling portion (122)； and an alignment means (126) arranged to maintain a preferred alignment between the stylet (104) and the cannula (102), wherein the alignment means (126) is arranged to align one or more of: i) relative rotation between the stylet distal end and the cannula distal end； ii) relative flexing between the stylet distal end and the cannula distal end； and iii) relative axial translation between the stylet distal end and the cannula distal end.
