Michael D. Altman,Brandon D. Cash,Matthew Lloyd Childers,Jared N. Cumming,Duane E. DeMong,Andrew Marc Haidle,Timothy J. Henderson,James P. Jewell,Matthew A. Larsen,Jongwon Lim,Min Lu,Ryan D. Otte,Benj
申请号：
US16372103
公开号：
US20190300513A1
申请日:
2019.04.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.
